" /> Zoptarelin Doxorubicin - CISMeF





Preferred Label : Zoptarelin Doxorubicin;

NCIt synonyms : Doxorubicin-GNRH Agonist Conjugate AEZS-108;

NCIt definition : A peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R) that is conjugated to the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates into DNA and inhibits the topoisomerase II activity, which may result in the inhibition of tumor cell DNA replication and tumor cell proliferation.;

UNII : 27844X2J29;

InChIKey : OOUACICUAVTCEC-LZHWUUGESA-N;

CAS number : 139570-93-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 139570-93-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AEZS-108; ZEN-008; AN-152; AN 152;

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16/05/2024


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