Zoptarelin Doxorubicin

Preferred Label : Zoptarelin Doxorubicin;

NCIt synonyms : Doxorubicin-GNRH Agonist Conjugate AEZS-108;

NCIt definition : A peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R) that is conjugated to the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates into DNA and inhibits the topoisomerase II activity, which may result in the inhibition of tumor cell DNA replication and tumor cell proliferation.;

UNII : 27844X2J29;

InChIKey : OOUACICUAVTCEC-LZHWUUGESA-N;

CAS number : 139570-93-7;

Molecule name : AEZS-108; ZEN-008; AN-152; AN 152;

Details

Origin ID

C74025;

UMLS CUI

C0658619;

Automatic exact mappings (from CISMeF team)
- LHRH, lysine(6)-doxorubicin [MeSH Supplementary Concept]
- LHRH, lysine(6)-doxorubicin [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- LHRH, lysine(6)-doxorubicin [MeSH Supplementary Concept]
- LHRH, lysine(6)-doxorubicin [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Gonadotropin-Releasing Hormone Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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