NCIt related terms : 6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing
Hormone-releasing Factor (Pig);
NCIt definition : A synthetic analog of gonadotropin-releasing hormone (GnRH). Buserelin binds to and
activates pituitary gonadotropin releasing hormone (GnRH) receptors. Prolonged administration
of buserelin results in sustained inhibition of gonadotropin production, suppression
of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin
and gonadal steroids. Buserelin is more potent that GnRH. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called gonadotropin-releasing
hormones. In prostate cancer therapy, buserelin blocks the production of testosterone
in the testicles.;