Histrelin - CISMeF

Preferred Label : Histrelin;

NCIt definition : A long-acting, synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) with potential anti-tumor activity. Upon administration, histrelin binds to and activates GnRH receptors; prolonged administration results in pituitary GnRH receptor desensitization and inhibition of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion, leading to a significant decline in testosterone production in males and may inhibit androgen receptor-positive tumor progression; in females, prolonged administration results in decreased estradiol production.;

UNII : H50H3S3W74;

InChIKey : HHXHVIJIIXKSOE-QILQGKCVSA-N;

CAS number : 76712-82-8;

Chemical formula : C66H86N18O12;

ChEBI ID : CHEBI:5739;

Codes from synonyms : 256;

Details

Origin ID

C74270;

UMLS CUI

C0121902;

Currated CISMeF NLP mapping
- Histrelin [ICD-11 Extension code]
- Histrelin [LOINC component]
- Histrelin (substance) [SNOMED CT concept]
- Product containing histrelin (medicinal product) [SNOMED CT concept]
- histrelin [MeSH concept]
- histrelin [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Histrelin [LOINC component]
- Histrelin (substance) [SNOMED CT concept]
- Product containing histrelin (medicinal product) [SNOMED CT concept]
- histrelin [ATC Code]
- histrelin [MeSH concept]
- histrelin [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- histrelin [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- Operational Ontology for Radiation Oncology Prostate Cancer Terminology [NCIt concept]
has_salt_form
- Histrelin Acetate [NCIt concept]
has_target
- Gonadotropin-Releasing Hormone Receptor [NCIt concept]
is_free_acid_or_base_form_of
- Histrelin Acetate [NCIt concept]

Keyword's position in hierarchy(ies) :

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