Histrelin Acetate

Preferred Label : Histrelin Acetate;

NCIt definition : The acetate salt form of histrelin, a long-acting, synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) with potential anti-tumor activity. Upon administration, histrelin binds to and activates GnRH receptors; prolonged administration results in pituitary GnRH receptor desensitization and inhibition of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion, leading to a significant decline in testosterone production in males and may inhibit androgen receptor-positive tumor progression; in females, prolonged administration results in decreased estradiol production.;

UNII : QMG7HLD1ZE;

InChIKey : BKEMVGVBBDMHKL-VYFXDUNUSA-N;

CAS number : 76712-82-8;

Drug name : Vantas; Supprelin;

Chemical formula : C66H86N18O12.C2H4O2.H2O;

Details

Origin ID

C77424;

UMLS CUI

C0724597;

Currated CISMeF NLP mapping
- Histrelin acetate (substance) [SNOMED CT concept]
- Supprelin [MeSH concept]
- histrelin acetate [International Nonproprietary Name]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Histrelin acetate (substance) [SNOMED CT concept]
- histrelin acetate [International Nonproprietary Name]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Histrelin [NCIt concept]
is_component_of_chemotherapy_regimen
- Histrelin Regimen [NCIt concept]
is_salt_form_of
- Histrelin [NCIt concept]

Keyword's position in hierarchy(ies) :

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