Preferred Label : GnRH Antagonist SHR7280;
NCIt synonyms : Gonadotropin-releasing Hormone Antagonist SHR7280;
NCIt definition : An orally bioavailable gonadotropin-releasing hormone (GnRH) receptor antagonist,
with potential hormone production inhibitory activity. Upon oral administration, GnRH
antagonist SHR7280 competes with GnRH for receptor binding and inhibits GnRH receptor
signaling in the anterior pituitary gland, thereby inhibiting the secretion and release
of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the
inhibition of LH secretion prevents the release of testosterone. Since testosterone
is required to sustain prostate growth, reducing testosterone levels may inhibit hormone-dependent
prostate cancer cell proliferation. In females, this prevents the production of estrogen
by the ovaries and may relieve symptoms from sex-hormone dependent diseases. Since
SHR7280 reduces the occurrence of premature LH surge in females, premature ovulation
is also prevented.;
Molecule name : SHR-7280; SHR 7280;
NCI Metathesaurus CUI : CL1794070;
Origin ID : C188795;
UMLS CUI : C5706512;
Semantic type(s)
- concept_is_in_subset
- has_target
