Abarelix - CISMeF

Preferred Label : Abarelix;

NCIt related terms : Plenaxis;

NCIt definition : A synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth.;

Alternative definition : NCI-GLOSS: A drug used to reduce the amount of testosterone made in patients with advanced symptomatic prostate cancer for which no other treatment options are available. It belongs to the family of drugs called gonadotropin-releasing hormone (GnRH) antagonists.;

UNII : W486SJ5824;

InChIKey : LNNDRFNNTDYHIO-OMYILHBOSA-N;

CAS number : 183552-38-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 183552-38-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : PPI-149; R-3827;

Chemical formula : C72H95ClN14O14;

ChEBI ID : CHEBI:337298;

Codes from synonyms : CDR0000367425; CDR0000367424; 3652;

Details

Origin ID

C2015;

UMLS CUI

C0965390;

Automatic exact mappings (from CISMeF team)
- Abarelix [ICD-11 Extension code]
Currated CISMeF NLP mapping
- abarelix [MeSH concept]
- abarelix [MeSH Supplementary Concept]
- plenaxis [MeSH concept]
False automatic mappings
- Abarelix (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing abarelix (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Abarelix (substance) [SNOMED CT concept]
- Product containing abarelix (medicinal product) [SNOMED CT concept]
- abarelix [ATC Code]
- abarelix [MeSH Supplementary Concept]
- abarelix [MeSH concept]
Validated automatic mappings to BTNT
- abarelix [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Gonadotropin-Releasing Hormone Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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