Leuprolide Acetate for Injectable Suspension TOL2506 - CISMeF
Leuprolide Acetate for Injectable Suspension TOL2506NCIt concept
Preferred Label : Leuprolide Acetate for Injectable Suspension TOL2506;
NCIt definition : A subcutaneous injectable suspension formulation containing the acetate salt form
of leuprolide, a synthetic nonapeptide analogue of gonadotropin-releasing hormone
(GnRH), with potential antineoplastic activity. Upon subcutaneous administration of
the leuprolide acetate for injectable suspension TOL2506, leuprolide binds to and
activates the gonadotropin-releasing hormone receptor (GnRHR). The continuous stimulation
of GnRHR by leuprolide results in both the desensitization of pituitary GnRHR and
the inhibition of pituitary secretion of the gonadotropins follicle stimulating hormone
(FSH) and luteinizing hormone (LH). In males, this results in a significant decline
in testosterone production to castration levels and may inhibit androgen receptor-positive
tumor progression. In females, this decreases estradiol production and level, suppresses
ovarian function and may inhibit proliferation of estrogen receptor (ER)-positive
breast cancer.;