" /> Leuprolide Acetate - CISMeF





Preferred Label : Leuprolide Acetate;

NCIt synonyms : LEUP; Leuprorelin Acetate; 6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig) Monoacetate; 6-D-Leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Pig) Monoacetate; Leuprolide;

NCIt related terms : Eligard; Lupron; Viadur;

NCIt definition : The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.;

Alternative definition : NCI-GLOSS: A drug used to treat symptoms of advanced prostate cancer. It is also being studied in the treatment of other conditions and types of cancer. The active ingredient leuprolide blocks the body from making testosterone (a male hormone) and estradiol (a female hormone). It may stop the growth of prostate cancer cells that need testosterone to grow. Some brands of leuprolide are also used to treat early puberty in children and certain gynecologic conditions. Leuprolide acetate is a type of gonadotropin-releasing hormone analog.;

UNII : 37JNS02E7V;

InChIKey : RGLRXNKKBLIBQS-XNHQSDQCSA-N;

CAS number : 74381-53-6;

Drug name : Ginecrin; Procren; Trenantone; Enantone; Procrin; Enantone-Gyn; Lupron Depot; Enanton; Uno-Enantone; Lupron; Lupron Depot-Ped; Carcinil; Lucrin; Prostap; Lupron Depot-3 Month; Lupron Depot-4 Month; Viadur; Leuplin; Lucrin Depot; Depo-Eligard; Lutrate; Luprodex Depot; Fensolvi;

Molecule name : Abbott 43818; Abbott-43818; A-43818; TAP-144; A 43818; TAP 144;

Chemical formula : C59H84N16O12.C2H4O2;

ChEBI ID : CHEBI:63597;

Codes from synonyms : CDR0000595341; CDR0000595348; CDR0000595349; CDR0000595347; 31429;

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08/05/2025


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