Leuprolide Mesylate

Preferred Label : Leuprolide Mesylate;

NCIt definition : The mesylate salt form of leuprolide, a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH), with potential antineoplastic activity. Upon administration, leuprolide binds to and activates the gonadotropin-releasing hormone receptor (GnRHR). The continuous stimulation of GnRHR by leuprolide results in both the desensitization of pituitary GnRHR and the inhibition of pituitary secretion of the gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH). In males, this results in a significant decline in testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.;

UNII : 8E3C3C493W;

CAS number : 944347-41-5;

Drug name : Camcevi;

NCI Metathesaurus CUI : CL1799374;

Details

Origin ID

C190727;

UMLS CUI

C5455243;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Leuprolide [NCIt concept]
has_target
- Gonadotropin-Releasing Hormone Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Leuprolide Mesylate Regimen [NCIt concept]
is_salt_form_of
- Leuprolide [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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