Mitogen-Activated Protein Kinase Kinase Kinase 4

Preferred Label : Mitogen-Activated Protein Kinase Kinase Kinase 4;

NCIt synonyms : MEKK 4; MAPK/ERK Kinase Kinase 4; Predicted Protein of HQ0412; MAP Three Kinase 1; EC 2.7.11.25; MAP/ERK Kinase Kinase 4; MAP3K4; MEK Kinase 4;

NCIt definition : Mitogen-activated protein kinase kinase kinase 4 (1608 aa, 182 kDa) is encoded by the human MAP3K4 gene. This protein plays a role in stress induced signaling pathways.;

NCIt note : Mitogen-activated protein kinase kinase kinase 4 (MAP3K4) phosphorylates mitogen-activated protein kinase kinase (MAP2K) 4 and MAP2K6. MAP3K4 has an N-terminal autoinhibitory domain that binds to the C-terminal kinase domain and prevents substrate interactions. GADD45 proteins activate MAP3K4 by binding to the N-terminal domain. (UniProt);

Details

Origin ID

C147957;

UMLS CUI

C1435745;

Automatic exact mappings (from CISMeF team)
- MAP kinase kinase kinase 4 [MeSH Descriptor]
- Mitogen-activated protein kinase kinase kinase 4 [OMIM gene]
- mitogen-activated protein kinase kinase kinase 4 [HGNC gene]
OMIM relation
- Mitogen-activated protein kinase kinase kinase 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAP3K4 protein, human [MeSH Supplementary Concept]
- MAP3K4 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAP3K4 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Stress Response Signaling [NCIt concept]
- Telomere Maintenance [NCIt concept]

Keyword's position in hierarchy(ies) :

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