SOS2 wt Allele

Preferred Label : SOS2 wt Allele;

NCIt synonyms : Son of Sevenless, Drosophilia, Homolog 2 Gene; NS9; Son of Sevenless Homolog 2 (Drosophila) Gene; Son of Sevenless (Drosophilia) Homolog 2 Gene; SOS-2; SOS Ras/Rho Guanine Nucleotide Exchange Factor 2 wt Allele;

NCIt definition : Human SOS2 wild-type allele is located in the vicinity of 14q21.3 and is approximately 114 kb in length. This allele, which encodes son of sevenless homolog 2 protein, is involved in the modulation of Ras signaling. Mutation of the gene is associated with Noonan syndrome 9.;

NCI Metathesaurus CUI : CL1643109;

GenBank Accession Number : L13858;

Details

Origin ID

C177165;

UMLS CUI

C5443953;

Automatic exact mappings (from CISMeF team)
- Noonan syndrome 9 [OMIM Phenotype]
- Noonan syndrome 9 [DO Concept]
OMIM relation
- Sos ras/rac guanine nucleotide exchange factor 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 14q21.3 [NCIt concept]
gene_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Acute Myeloid Leukemia Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Human Cytomegalovirus Infection Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_plays_role_in_process
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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