Matrix Metalloproteinase-14

Preferred Label : Matrix Metalloproteinase-14;

NCIt synonyms : Matrix Metalloproteinase 14; Membrane-Type-1 Matrix Metalloproteinase; MMP-X1; Membrane-Type Matrix Metalloproteinase 1; MTMMP1; MT1-MMP; MMP14; Membrane-Inserted Matrix Metalloproteinase; MT-MMP1; MT1MMP; EC 3.4.24.80; MMP-14;

NCIt definition : Matrix metalloproteinase-14 (582 aa, 66 kDa) is encoded by the human MMP14 gene. This protein is involved in both extracellular matrix proteolysis and the activation of 72 kDa type IV collagenase.;

Details

Origin ID

C41050;

UMLS CUI

C0671550;

Currated CISMeF NLP mapping
- matrix metalloproteinase 14 [MeSH Descriptor]
- matrix metalloproteinase 14 [MeSH concept]
OMIM relation
- Matrix metalloproteinase 14 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MMP14 protein, human [MeSH concept]
- MMP14 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- MMP14 Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Rebimastat [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Metal Binding Site [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_is_element_in_pathway
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Inhibition of Matrix Metalloproteinases Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Proteolysis [NCIt concept]
is_target
- Rebimastat [NCIt concept]

Keyword's position in hierarchy(ies) :

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