Mitogen-Activated Protein Kinase 7

Preferred Label : Mitogen-Activated Protein Kinase 7;

NCIt synonyms : BMK1 Kinase; Extracellular Signal-Regulated Kinase 5; MAPK7; BMK-1; EC 2.7.11.24; MAP Kinase 7; Big MAP kinase 1; ERK-5; MAPK 7; MAP-Kinase-7;

NCIt definition : Mitogen-activated protein kinase 7 (816 aa, 88 kDa) is encoded by the human MAPK7 gene. This protein is involved in serine/threonine phosphorylation, transcription factor phosphorylation and signaling.;

NCIt note : Autophosphorylated and likely activated by tyrosine and threonine phosphorylation by upstream kinase, MAPK7 translocates to the nucleus in response to extracellular signals and regulates gene expression by phosphorylating and activating target transcription factors. The C-terminus may have an autoregulatory role, and the second Pro-rich region may interact with actin, targeting MAPK7 to specific cell locations.;

Details

Origin ID

C26378;

UMLS CUI

C1174318;

Automatic exact mappings (from CISMeF team)
- KAS-1 toxin, buthus martensi [MeSH Supplementary Concept]
OMIM relation
- Mitogen-activated protein kinase 7 [OMIM gene]
See also inter- (CISMeF)
- Mitogen-activated protein kinase 7 [OMIM gene]
- mitogen-activated protein kinase 7 [HGNC gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAPK7 protein, human [MeSH Supplementary Concept]
- MAPK7 protein, human [MeSH concept]
Validated automatic mappings to NTBT
- Mitogen-Activated protein kinase 7 [MeSH concept]
- Mitogen-Activated protein kinase 7 [MeSH Descriptor]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAP Kinase Gene [NCIt concept]
- MAPK7 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Heart [NCIt concept]
- Kidney [NCIt concept]
- Lung [NCIt concept]
- Placenta [NCIt concept]
- Skeletal Muscle Tissue [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Gap Junction Assembly Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- Neuronal Survival Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Skeletal Myogenesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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