MAPK7 wt Allele

Preferred Label : MAPK7 wt Allele;

NCIt synonyms : Mitogen-Activated Protein Kinase 7 wt Allele; ERK4; ERK5; PRKM7; BMK1;

NCIt definition : Human MAPK7 wild-type allele is located in the vicinity of 17p11.2 and is approximately 6 kb in length. This allele, which encodes mitogen-activated protein kinase 7 protein, plays a role in the activation of nuclear transcription factors in response to extracellular signals. The MAPK7 gene is overexpressed in prostate cancer.;

NCIt note : The MAPK7 gene exhibits high levels of expression in the heart, kidneys, liver, lungs, placenta and skeletal muscle. This gene produces three RNA transcript variants which encode distinct isoforms of mitogen-activated protein kinase 7 protein.;

GenBank Accession Number : NM_002749;

Details

Origin ID

C51258;

UMLS CUI

C1708804;

OMIM relation
- Mitogen-activated protein kinase 7 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 17p11.2 [NCIt concept]
gene_is_element_in_pathway
- Gap Junction Assembly Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- Neuronal Survival Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Skeletal Myogenesis Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Cycle Regulation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients