Mitogen-Activated Protein Kinase 11

Preferred Label : Mitogen-Activated Protein Kinase 11;

NCIt synonyms : MAPK11; Mitogen-Activated Protein Kinase P38-2; Stress-Activated Protein Kinase-2; Stress-Activated Protein Kinase 2b; EC 2.7.11.24; SAPK2b; Mitogen-Activated Protein Kinase p38 Beta; MAPK 11; MAP Kinase p38 Beta; p38-2; p38b; MAP Kinase 11; MAP-Kinase-11;

NCIt definition : Mitogen-activated protein kinase 11 (364 aa, 41 kDa) is encoded by the human MAPK11 gene. This protein plays a role in serine/threonine phosphorylation and the MAP kinase signaling pathway.;

NCIt note : MAPK11 is most closely related to p38 MAP kinase; both can be activated by proinflammatory cytokines and environment stress. MAPK11 is activated through phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of MAPK11.;

Details

Origin ID

C26364;

UMLS CUI

C1456378;

OMIM relation
- Mitogen-activated protein kinase 11 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAP Kinase Gene [NCIt concept]
- MAPK11 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Heart [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Amyotrophic Lateral Sclerosis Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- NFKB Activation Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Ralimetinib Mesylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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