Heparin-Binding EGF-Like Growth Factor

Preferred Label : Heparin-Binding EGF-Like Growth Factor;

NCIt synonyms : HBEGF; DTR; Diphtheria Toxin Sensitivity; DTR Protein; HEGFL; HB-EGF; DTS; DT-R; Heparin-Binding EGF; Diphtheria Toxin Receptor;

NCIt definition : Heparin-binding EGF-like growth factor (86 aa, 10 kDa) is encoded by the human HBEGF gene. This protein is involved in both heart development and mitogenesis.;

NCIt note : The active form of the growth factor, called heparin-binding EGF-like growth factor, is produced by two proteolytic cleavage events that remove 62 N-terminal amino acids and 60 amino acids from the C-terminus of proheparin-binding EGF-like growth factor. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt);

Details

Origin ID

C26123;

UMLS CUI

C3884528;

Automatic exact mappings (from CISMeF team)
- Due to (attribute) [SNOMED CT concept]
- Heparin-binding EGF-like Growth Factor [MeSH Descriptor]
- Heparin-binding EGF-like Growth Factor [MeSH concept]
- Heparin-binding Epidermal Growth Factor-like Growth Factor Precursor Protein [MeSH concept]
- Heparin-binding egf-like growth factor [OMIM gene]
- Product containing diphtheria toxoid and tetanus toxoid adsorbed (medicinal product) [SNOMED CT concept]
- drug therapy [MeSH Descriptor]
OMIM relation
- Heparin-binding egf-like growth factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HBEGF protein, human [MeSH concept]
- HBEGF protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- HBEGF Gene [NCIt concept]
gene_product_expressed_in_tissue
- Fibroblast [NCIt concept]
- Smooth Muscle Cell [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Heparin Binding Growth Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
gene_product_is_element_in_pathway
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB4 Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Family Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Lysophosphatidic Acid Receptor Signaling Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
- Plasma Membrane Estrogen Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Heparin Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Anti-HB-EGF Monoclonal Antibody KHK2866 [NCIt concept]
- Anti-HBEGF Monoclonal Antibody U3-1565 [NCIt concept]

Keyword's position in hierarchy(ies) :

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