Anti-HB-EGF Monoclonal Antibody KHK2866

Preferred Label : Anti-HB-EGF Monoclonal Antibody KHK2866;

NCIt synonyms : Anti-HB-EGF MoAb KHK2866;

NCIt related terms : KHK-2866;

NCIt definition : A proprietary fucose-free monoclonal antibody directed against human heparin-binding EGF-like growth factor (HBEGF) with potential antineoplastic activity. Anti-HB-EGF Monoclonal Antibody KHK2866 binds to HBEGF, thereby blocking its binding to the EGF receptors. This prevents EGF receptor activation and the subsequent induction of cell growth signaling. HBEGF is mitogenic for fibroblasts and smooth muscle and may be involved in macrophage-mediated cellular proliferation. The fucose-free monoclonal antibodies enhance antigen dependent cellular cytotoxicity (ADCC), and increase binding affinity to the Fc Receptor to overcome genetic polymorphism.;

UNII : 111EN0IJ7C;

CAS number : 1832713-21-9;

Molecule name : KHK2866;

NCI Metathesaurus CUI : CL428183;

Details

Origin ID

C95721;

UMLS CUI

C2987372;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Heparin-Binding EGF-Like Growth Factor [NCIt concept]

Keyword's position in hierarchy(ies) :

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