GTPase KRas - CISMeF

Preferred Label : GTPase KRas;

NCIt synonyms : c-K-Ras Protein; K-Ras-2 p21; KRAS2; K-Ras 2A; Ki-Ras; c-K-Ras; K-Ras p21 Protein; K-Ras-2 Protein; KRAS; K-Ras 2; p21 K-Ras Protein; c-Ki-ras;

NCIt definition : GTPase KRas (189 aa, 21 kDa) is encoded by the human KRAS gene. This protein is involved in the regulation of GTP metabolism and in signaling.;

NCIt note : There are at least 2 isoforms of GTPase KRas called K-Ras4A and K-Ras4B. These osoforms differ in the C-terminal region which is encoded by two alternative exons (IVA and IVB). UniProt considers K-Ras4A the canonical isoform.;

Details

Origin ID

C17383;

UMLS CUI

C0763464;

Automatic exact mappings (from CISMeF team)
- KRAS proto-oncogene, GTPase [ORDO Gene]
- Kras protooncogene, gtpase [OMIM gene]
- crk-associated substrate protein [MeSH Descriptor]
- k-ras [EMDN type]
- k-ras [medical devices type]
OMIM relation
- Kras protooncogene, gtpase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- KRAS protein, human [MeSH Supplementary Concept]
- KRAS protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- KRAS Gene [NCIt concept]
- RAS Family Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_biochemical_function
- GTPase [NCIt concept]
gene_product_has_gene_product_variant
- KRAS NP_004976.2:p.A146T [NCIt concept]
- KRAS NP_004976.2:p.A146X [NCIt concept]
- KRAS NP_004976.2:p.A59X [NCIt concept]
- KRAS NP_004976.2:p.G12A [NCIt concept]
- KRAS NP_004976.2:p.G12C [NCIt concept]
- KRAS NP_004976.2:p.G12D [NCIt concept]
- KRAS NP_004976.2:p.G12E [NCIt concept]
- KRAS NP_004976.2:p.G12F [NCIt concept]
- KRAS NP_004976.2:p.G12I [NCIt concept]
- KRAS NP_004976.2:p.G12L [NCIt concept]
- KRAS NP_004976.2:p.G12N [NCIt concept]
- KRAS NP_004976.2:p.G12R [NCIt concept]
- KRAS NP_004976.2:p.G12S [NCIt concept]
- KRAS NP_004976.2:p.G12V [NCIt concept]
- KRAS NP_004976.2:p.G12W [NCIt concept]
- KRAS NP_004976.2:p.G12X [NCIt concept]
- KRAS NP_004976.2:p.G12Y [NCIt concept]
- KRAS NP_004976.2:p.G13A [NCIt concept]
- KRAS NP_004976.2:p.G13C [NCIt concept]
- KRAS NP_004976.2:p.G13D [NCIt concept]
- KRAS NP_004976.2:p.G13E [NCIt concept]
- KRAS NP_004976.2:p.G13N [NCIt concept]
- KRAS NP_004976.2:p.G13R [NCIt concept]
- KRAS NP_004976.2:p.G13S [NCIt concept]
- KRAS NP_004976.2:p.G13V [NCIt concept]
- KRAS NP_004976.2:p.G13X [NCIt concept]
- KRAS NP_004976.2:p.K117X [NCIt concept]
- KRAS NP_004976.2:p.Q61D [NCIt concept]
- KRAS NP_004976.2:p.Q61E [NCIt concept]
- KRAS NP_004976.2:p.Q61H [NCIt concept]
- KRAS NP_004976.2:p.Q61K [NCIt concept]
- KRAS NP_004976.2:p.Q61L [NCIt concept]
- KRAS NP_004976.2:p.Q61P [NCIt concept]
- KRAS NP_004976.2:p.Q61R [NCIt concept]
- KRAS NP_004976.2:p.Q61X [NCIt concept]
- KRAS Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- GTP Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Axon Guidance Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- Bladder Cancer Pathway [NCIt concept]
- CXCR3-Mediated Signaling Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Class I PI3K Signaling Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB2/ERBB3 Signaling Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Ephrin B Forward Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- IL2-Mediated Signaling Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Internalization Pathway for Epidermal Growth Factor Receptor [NCIt concept]
- Long-Term Depression Pathway [NCIt concept]
- Long-Term Potentiation Pathway [NCIt concept]
- Melanogenesis Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- NTRK1/MAPK Signaling Pathway [NCIt concept]
- NTRK1/PI3K/PLC-Gamma Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Papillary Thyroid Carcinoma Pathway [NCIt concept]
- Plasma Membrane Estrogen Receptor Signaling Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Ras Signaling in the CD4+ TCR Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- Telomere Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
- mTOR Signaling Pathway PID [NCIt concept]
gene_product_plays_role_in_biological_process
- GTP Binding [NCIt concept]
- Hydrolysis [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Berzofsky Ras/P53 Peptide Vaccine [NCIt concept]
- cEt KRAS Antisense Oligonucleotide AZD4785 [NCIt concept]
- siG12D LODER [NCIt concept]

Keyword's position in hierarchy(ies) :

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