Preferred Label : siG12D LODER;
NCIt definition : A proprietary, miniature biodegradable polymeric matrix containing small-interfering
RNAs for the mutated KRAS oncogene, KRASG12D, (siG12D), with potential antitumor activity.
Upon intratumoral injection, this siG12D is released locally, thereby preventing translation
of KRAS proteins and potentially inhibiting growth of tumor cells overexpressing KRAS.
KRAS, a member of the small GTPase superfamily, is mutated in over 90% of human pancreatic
ductal adenocarcinomas (PDAC) and is associated with tumor cell proliferation and
reduced survival.;
UNII : NNQ0PKZ9EV;
NCI Metathesaurus CUI : CL428214;
Origin ID : C95772;
UMLS CUI : C2987413;
Semantic type(s)
- concept_is_in_subset
- has_target
