Preferred Label : cEt KRAS Antisense Oligonucleotide AZD4785;
NCIt synonyms : cEt KRAS ASO AZD4785; Generation 2.5 Drug AZD4785; IONIS-KRAS-2.5Rx; ASO AZD4785;
NCIt related terms : AZD-4785;
NCIt definition : A proprietary formulation composed of a high affinity antisense oligonucleotide (ASO)
that contains 2'-4' constrained ethyl residues (cEt) and targets KRAS (K-RAS) transcripts,
with potential antineoplastic activity. Upon intravenous administration, cEt KRAS
antisense oligonucleotide AZD4785 targets and binds, with high affinity, to a unique
genetic sequence within KRAS messenger RNA (mRNA), thereby inhibiting translation
of KRAS protein, including forms containing activating mutations. Inhibition of KRAS
protein synthesis prevents KRAS-dependent signaling and inhibits the proliferation
of KRAS-driven tumor cells. KRAS, a tumor-associated antigen (TAA), is mutated in
a variety of tumor cell types. It plays a key role in tumor cell proliferation and
survival and is associated with tumor initiation, metastasis and poor prognosis.;
UNII : D43WWD6RDZ;
Molecule name : AZD 4785; AZD-4785;
NCI Metathesaurus CUI : CL545331;
Origin ID : C147521;
UMLS CUI : C4687975;
Semantic type(s)
- concept_is_in_subset
- has_target
