Mitogen-Activated Protein Kinase 9

Preferred Label : Mitogen-Activated Protein Kinase 9;

NCIt synonyms : C-Jun Kinase 2; C-Jun N-Terminal Kinase 2; Stress-Activated Protein Kinase JNK2; MAPK9; Jun Kinase; SAPK1a; JNK-55; MAPK 9; Stress-Activated Protein Kinase 1a; MAP Kinase 9; EC 2.7.11.24; MAP-Kinase-9;

NCIt definition : Mitogen-activated protein kinase 9 (424 aa, 48 kDa) is encoded by the human MAPK9 gene. This protein is involved in cytokine signaling, protein phosphorylation and transcriptional regulation.;

NCIt note : MAPK9 mediates immediate-early gene expression. MAPK9 binds scaffolding proteins MAPK8IP1/2/3. MAPK9/UV-induced apoptosis appears related to cytochrome c-mediated cell death. Increased p53 stability in nonstressed cells results from MAPK9 blocked p53 ubiquitination. MAPK9 appears required for T-helper cell differentiation into Th1 cells.;

Details

Origin ID

C26379;

UMLS CUI

C1367019;

OMIM relation
- Mitogen-activated protein kinase 9 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
Validated automatic mappings to NTBT
- Mitogen-Activated protein kinase 9 [MeSH Descriptor]
- Mitogen-Activated protein kinase 9 [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAP Kinase Gene [NCIt concept]
- MAPK9 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adipocytokine Signaling Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- Shigellosis Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Stress Response Signaling [NCIt concept]
- T-Cell Proliferation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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