14-3-3 Protein Sigma

Preferred Label : 14-3-3 Protein Sigma;

NCIt synonyms : 14-3-3 Sigma; SFN; Epithelial Cell Marker Protein 1; Stratifin;

NCIt definition : 14-3-3 protein sigma (248 aa, 28 kDa) is encoded by the human SFN gene. This protein plays a role in adaptor signal protein functions.;

NCIt note : 14-3-3 protein sigma may act as a p53-regulated homodimeric inhibitor of G2/M progression. (Cell Cycle. 2008; 7:670-682.);

Details

Origin ID

C26474;

UMLS CUI

C0972212;

OMIM relation
- Stratifin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Indicator, Reagent, or Diagnostic Aid [UMLS semantic type]
UMLS correspondences (same concept)
- SFN protein, human [MeSH Supplementary Concept]
- SFN protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- SFN Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_expressed_in_tissue
- Epithelial Cell [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_is_element_in_pathway
- Aldosterone-Regulated Sodium Reabsorption Pathway [NCIt concept]
- Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- EFP Cell Cycle Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- FOXO Transcription Factor Family Signaling Pathway [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
- Insulin-Mediated Glucose Transport Pathway [NCIt concept]
- LKB1 Signaling Pathway [NCIt concept]
- NTRK1/PI3K/PLC-Gamma Signaling Pathway [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- PI3K/AKT1 Signaling Pathway [NCIt concept]
- mTOR Signaling Pathway PID [NCIt concept]
- p38 MAPK/MAPKAP Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Negative Regulation of Cell Cycle [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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