Insulin Receptor

Preferred Label : Insulin Receptor;

NCIt synonyms : INSR; CD220 Antigen; IR; Antigen CD220; EC 2.7.10.1; CD220;

NCIt definition : Insulin receptor (1382 aa, 156 kDa) is encoded by the human INSR gene. This protein plays a role in both signal transduction and glucose homeostasis.;

NCIt note : Insulin receptor is cleaved to generate and alpha chain and a beta chain. The mature receptor is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. (UniProt);

Details

Origin ID

C17072;

UMLS CUI

C1448132;

Currated CISMeF NLP mapping
- receptor, insulin [MeSH Descriptor]
- receptor, insulin [MeSH concept]
False automatic mappings
- Insulin receptor (substance) [SNOMED CT concept]
- insulin receptor (1293-1307) [MeSH concept]
- insulin receptor (1293-1307) [MeSH Supplementary Concept]
OMIM relation
- Insulin receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- INSR protein, human [MeSH concept]
- INSR protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- INSR Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Growth Factor Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Cell Surface Receptor [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adherens Junction Assembly Pathway [NCIt concept]
- Aldosterone-Regulated Sodium Reabsorption Pathway [NCIt concept]
- Growth Hormone Signaling Pathway [NCIt concept]
- Insulin Pathway [NCIt concept]
- Insulin Signaling Pathway [NCIt concept]
- Insulin-Mediated Glucose Transport Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- PTPN1 Signaling Pathway [NCIt concept]
- Skeletal Myogenesis Pathway [NCIt concept]
- Type II Diabetes Mellitus Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Diabetes Mellitus [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Dual IGF-1R/InsR Inhibitor BMS-754807 [NCIt concept]
- IGF-1R/IR Inhibitor KW-2450 [NCIt concept]
- Insulin Aspart [NCIt concept]
- Insulin Glargine [NCIt concept]
- Insulin, NPH [NCIt concept]
- Therapeutic Insulin [NCIt concept]

Keyword's position in hierarchy(ies) :

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