receptor, insulin

Preferred Label : receptor, insulin;

MeSH definition : A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.;

MeSH synonym : receptors, insulin; insulin receptors; insulin-dependent tyrosine protein kinase; insulin receptor; insulin receptor protein-tyrosine kinase; insulin receptor protein tyrosine kinase;

CISMeF synonym : EC 2.7.1.112;

MeSH hyponym : insulin receptor beta subunit; insulin receptor alpha subunit; Insulin Receptor beta Chain; Insulin Receptor alpha Chain;

Registry Number MeSH : EC 2.7.10.1;

Wikipedia link : https://en.wikipedia.org/wiki/Insulin receptor;

Is substance : O;

UNII : EC 2.7.10.1;

Details

Origin ID

D011972;

UMLS CUI

C0034818;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Insulin Receptor [NCIt concept]
Indexing information
- 2,5-dihydroxy-6-(1-methylindol-3-yl)-3-phenyl-1,4-benzoquinone [MeSH Supplementary Concept]
- 6-chloro-6-deoxy-1,2,3,4-tetra-O-galloylglucopyranose [MeSH Supplementary Concept]
- AGL 2263 [MeSH Supplementary Concept]
- AP3S1 protein, human [MeSH Supplementary Concept]
- GRB10 protein, human [MeSH Supplementary Concept]
- IRS3P protein, human [MeSH Supplementary Concept]
- Irs3 protein, mouse [MeSH Supplementary Concept]
- Irs3 protein, rat [MeSH Supplementary Concept]
- S661 peptide [MeSH Supplementary Concept]
- S961 peptide [MeSH Supplementary Concept]
- insulin receptor peptide (1135-1156) [MeSH Supplementary Concept]
- insulin receptor tyrosine kinase [MeSH Supplementary Concept]
- insulin-stimulated phosphoprotein pp105 [MeSH Supplementary Concept]
- taurine receptor [MeSH Supplementary Concept]
Record concept(s)
- insulin receptor alpha subunit [MeSH concept]
- insulin receptor beta subunit [MeSH concept]
- receptor, insulin [MeSH concept]
Related MeSH Supplementary Concept(s)
- DAF-2 protein, C elegans [MeSH Supplementary Concept]
- INSR protein, human [MeSH Supplementary Concept]
- Insr protein, rat [MeSH Supplementary Concept]
- Insra protein, zebrafish [MeSH Supplementary Concept]
- Insrb protein, zebrafish [MeSH Supplementary Concept]
- aglycoinsulin receptor [MeSH Supplementary Concept]
- daf-28 protein, C elegans [MeSH Supplementary Concept]
- insulin proreceptor [MeSH Supplementary Concept]
- insulin receptor (1293-1307) [MeSH Supplementary Concept]
- insulin receptor peptide (1135-1156) [MeSH Supplementary Concept]
- insulin receptor serine kinase [MeSH Supplementary Concept]
- insulin receptor-related receptor [MeSH Supplementary Concept]
See also
- donohue syndrome [MeSH Descriptor]
- insulin [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- Insulin receptor [LOINC component]
- Insulin receptor (substance) [SNOMED CT concept]
- insulin receptor site [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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