NCIt definition : An orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R)
and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity.
IGF-1R/IR inhibitor KW-2450 selectively binds to and inhibits the activities of IGF-1R
and IR, which may result in the inhibition of tumor cell proliferation and the induction
of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety
of human cancers, play significant roles in the stimulation of cellular proliferation,
oncogenic transformation, and suppression of apoptosis.;
UNII : 2TRH1EX32K;
CAS number : 1360433-93-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1360433-93-7
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