NCIt definition : An orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R)
and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity.
IGF-1R/IR inhibitor KW-2450 selectively binds to and inhibits the activities of IGF-1R
and IR, which may result in the inhibition of tumor cell proliferation and the induction
of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety
of human cancers, play significant roles in the stimulation of cellular proliferation,
oncogenic transformation, and suppression of apoptosis.;