" /> IGF-1R/IR Inhibitor KW-2450 - CISMeF





Preferred Label : IGF-1R/IR Inhibitor KW-2450;

NCIt related terms : KW-2450;

NCIt definition : An orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis.;

UNII : 2TRH1EX32K;

CAS number : 1360433-93-7;

Molecule name : KW-2450;

NCI Metathesaurus CUI : CL412997;

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07/05/2025


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