" /> Dual IGF-1R/InsR Inhibitor BMS-754807 - CISMeF





Preferred Label : Dual IGF-1R/InsR Inhibitor BMS-754807;

NCIt synonyms : IGF1R Antagonist BMS-754807;

NCIt related terms : BMS-754807;

NCIt definition : An oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity. Dual IGF-IR/InsR inhibitor BMS-754807 binds reversibly to and inhibits the activities of IGF-1R and InsR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R and InsR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in mitogenesis, angiogenesis, and tumor cell survival.;

UNII : W9E3353E8J;

InChIKey : LQVXSNNAFNGRAH-QHCPKHFHSA-N;

CAS number : 1001350-96-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1001350-96-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BMS-754807;

Chemical formula : C23H26FN9O;

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14/05/2024


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