Dual IGF-1R/InsR Inhibitor BMS-754807

Preferred Label : Dual IGF-1R/InsR Inhibitor BMS-754807;

NCIt synonyms : IGF1R Antagonist BMS-754807;

NCIt related terms : BMS-754807;

NCIt definition : An oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity. Dual IGF-IR/InsR inhibitor BMS-754807 binds reversibly to and inhibits the activities of IGF-1R and InsR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R and InsR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in mitogenesis, angiogenesis, and tumor cell survival.;

UNII : W9E3353E8J;

InChIKey : LQVXSNNAFNGRAH-QHCPKHFHSA-N;

CAS number : 1001350-96-4;

Molecule name : BMS-754807;

Chemical formula : C23H26FN9O;

Details

Origin ID

C74043;

UMLS CUI

C2346450;

Currated CISMeF NLP mapping
- BMS 754807 [MeSH Supplementary Concept]
- BMS 754807 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BMS 754807 [MeSH Supplementary Concept]
- BMS 754807 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Insulin Receptor [NCIt concept]
- Insulin-Like Growth Factor 1 Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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