Erythrocyte Differentiation Pathway

Preferred Label : Erythrocyte Differentiation Pathway;

Alternative definition : BIOCARTA: Stem cells in the bone marrow produce a variety of hematopoietic cell types from common progenitor cells under the influence of cytokines and growth factors. CFU-GEMM cells are a key intermediate in the differentiation of granulocytes, erythrocytes, monocytes and megakaryocytes. Erythropoietin (EPO) is a cytokine produced in the kidneys that, along with other cytokines, induces red blood cell (erythrocyte) differentiation in the bone marrow from CFU-GEMM cells. As the erythrocyte lineage progresses, cells lose their nuclei, and move out of the bone marrow into circulation. The ability of EPO to selectively induce red blood cell differentiation has allowed extensive therapeutic use of the recombinant form of this cytokine to treat anemias. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_erythPathway;

Details

Origin ID

C39073;

UMLS CUI

C1516959;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- C-C Motif Chemokine 3 [NCIt concept]
- Erythropoietin [NCIt concept]
- Granulocyte Colony-Stimulating Factor [NCIt concept]
- Granulocyte-Macrophage Colony-Stimulating Factor [NCIt concept]
- Insulin-Like Growth Factor I [NCIt concept]
- Interleukin-1 Alpha [NCIt concept]
- Interleukin-10 [NCIt concept]
- Interleukin-3 [NCIt concept]
- Interleukin-6 [NCIt concept]
- Interleukin-9 [NCIt concept]
- Kit Ligand [NCIt concept]
- Receptor-Type Tyrosine-Protein Kinase FLT3 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
pathway_has_gene_element
- CCL3 wt Allele [NCIt concept]
- CSF2 wt Allele [NCIt concept]
- CSF3 wt Allele [NCIt concept]
- EPO wt Allele [NCIt concept]
- FLT3 wt Allele [NCIt concept]
- IGF1 wt Allele [NCIt concept]
- IL11 wt Allele [NCIt concept]
- IL1A wt Allele [NCIt concept]
- IL3 wt Allele [NCIt concept]
- IL6 wt Allele [NCIt concept]
- IL9 wt Allele [NCIt concept]
- KITLG wt Allele [NCIt concept]
- KLF1 wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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