Granulocyte-Macrophage Colony-Stimulating Factor

Preferred Label : Granulocyte-Macrophage Colony-Stimulating Factor;

NCIt synonyms : GM CSF; Colony Stimulating Factor, Granulocyte-Macrophage; Colony-Stimulating Factor; CSF; Granulocyte Macrophage Colony Stimulating Factor; GMCSF; CSF2; Granulocyte Macrophage Colony-Stimulating Factor; Granulocyte-Macrophage Colony Stimulating Factor; Colony-Stimulating Factor 2; Colony Stimulating Factor 2; Colony Stimulating Factor-2;

NCIt related terms : GM-CSF;

NCIt definition : Granulocyte-macrophage colony-stimulating factor (144 aa, 16 kDa) is encoded by the human CSF2 gene. This protein plays a role in the positive regulation of the growth and differentiation of cells in the granulocyte, macrophage, eosinophil and erythrocyte lineages.;

Alternative definition : NCI-GLOSS: A substance that helps make more white blood cells, especially granulocytes, macrophages, and cells that become platelets. It is a cytokine that is a type of hematopoietic (blood-forming) agent.;

NCIt note : The active form of the protein is found extracellularly as a homodimer.;

NCI Metathesaurus CUI : CL1374956;

Codes from synonyms : CDR0000046073; CDR0000423043;

Details

Origin ID

C20545;

UMLS CUI

C5197246;

Automatic exact mappings (from CISMeF team)
- Cerebral spinal fluid [LOINC part]
- Cerebral spinal fluid [LOINC System]
- Cerebrospinal fluid index (procedure) [SNOMED CT concept]
- Portion of cerebrospinal fluid [FMA entity]
- cerebrospinal fluid [UBERON concept]
- granulocyte macrophage colony-stimulating factor receptor activity [GO term]
- granulocyte macrophage colony-stimulating factor receptor binding [GO term]
- granulocyte-macrophage colony-stimulating factor-positive [COVID-19 Thesaurus concept]
- interleukin 3 [HGNC gene]
- interleukin 5 [HGNC gene]
Currated CISMeF NLP mapping
- Colony-stimulating factor, granulocyte-macrophage (substance) [SNOMED CT concept]
- Granulocyte macrophage colony stimulating factor [LOINC component]
- Granulocyte-Macrophage Colony-Stimulating factor [MeSH concept]
- colony-stimulating factor, granulocyte-macrophage [SNOMED Notion]
- granulocyte-macrophage colony-stimulating factor [Blood Transfusion thesaurus concept]
- granulocyte-macrophage colony-stimulating factor [MeSH Descriptor]
OMIM relation
- Colony-stimulating factor 2 [OMIM gene]
See also inter- (CISMeF)
- Colony stimulating factor (substance) [SNOMED CT concept]
- Colony-Stimulating factors [MeSH concept]
- Colony-stimulating factor 2 [OMIM gene]
- Product containing colony stimulating factor (product) [SNOMED CT concept]
- colony stimulating factor 2 [HGNC gene]
- colony stimulating factors [ATC Code]
- colony-stimulating factor, nos [SNOMED Notion]
- colony-stimulating factors [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CSF2 protein, human [MeSH Supplementary Concept]
- Colony-stimulating factor, granulocyte-macrophage (substance) [SNOMED CT concept]
- Granulocyte-Macrophage Colony-Stimulating factor [MeSH concept]
- colony-stimulating factor, granulocyte-macrophage [SNOMED Notion]
- granulocyte-macrophage colony-stimulating factor [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CSF2 Gene [NCIt concept]
- Colony-Stimulating Factor Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
- Hematopoietic Factor Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Namilumab [NCIt concept]
gene_product_has_associated_anatomy
- Bone Marrow [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
- Lymphokine [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_is_element_in_pathway
- Allergy Chemokine Network Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- Calcium Signaling in the CD4+ TCR Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Dendritic Cell Pathway [NCIt concept]
- Erythrocyte Differentiation Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
- Hematopoiesis Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- Inflammatory Response Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Regulation of Retinoblastoma Protein Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- Syndecan-2-Mediated Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- T-Cell Polarization Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukopoiesis [NCIt concept]
is_target
- Lenzilumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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