C-C Motif Chemokine 3

Preferred Label : C-C Motif Chemokine 3;

NCIt synonyms : CCL3; LD78; Stem Cell Inhibitor; MIP-1 Alpha; MIP-1a; Chemokine (C-C motif) Ligand 3; MIP-1-alpha; Small Inducible Cytokine A3; PAT 464.1; Small Inducible Cytokine-A3; Macrophage Inflammatory Protein 1-Alpha; Tonsillar Lymphocyte LD78 Alpha Protein; G0/G1 Switch Regulatory Protein 19-1; LD78-Alpha; Small-Inducible Cytokine A3; SIS-Beta;

NCIt definition : C-C motif chemokine 3 (92 aa, 10 kDa) is encoded by the human CCL3 gene. This protein is involved in both the inhibition of HIV binding to C-C chemokine receptor type 5 and the regulation of neutrophil and monocyte chemotaxis.;

NCIt note : C-C motif chemokine 3 is processed to form MIP-1-alpha(4-69). The active form of the chemokine is either a homodimer or a heterodimer comprised of MIP-1-alpha(4-69) and MIP-1-beta(3-69). (UniProt);

Details

Origin ID

C20481;

UMLS CUI

C1871788;

OMIM relation
- Chemokine, CC motif, ligand 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- CCL3 protein, human [MeSH concept]
- CCL3 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- CC Cytokine Gene [NCIt concept]
- CCL3 Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Macrophage Inflammatory Protein [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_is_element_in_pathway
- Chagas Disease Pathway [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Erythrocyte Differentiation Pathway [NCIt concept]
- IL12-Mediated Signaling Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- T-Cell Polarization Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Antibacterial Response [NCIt concept]
- Antiviral Response [NCIt concept]
- Chemotactic Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Immunoregulation [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients