IGF-1 Signaling Pathway

Preferred Label : IGF-1 Signaling Pathway;

Alternative definition : BIOCARTA: Insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) provide a potent proliferative signaling system that stimulates growth in many different cell types and blocks apoptosis. In vivo IGF-1 acts as an intermediate of many growth hormone responses, and may stimulate the growth of some types of cancer. IGF-1 also provides a mitogenic signal to act as a growth factor for many tissue culture cells. One component of IGF-1 mitogenic signaling is association of the receptor tyrosine kinase with Shc, Grb2, and Sos-1 to activate ras and the Map kinase cascade (raf, Mek, Erk). An endpoint of the Map kinase pathway is modification of transcription factor activity, such as activation of ELK transcription factors. Serum response factor (SRF) and AP-1 contribute to mitogenic signaling by many factors. Phosphorylation of IRS-1 and PI3 kinase activation are also involved in IGF-1 signaling, similar to insulin signaling. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_igf1Pathway;

Details

Origin ID

C39114;

UMLS CUI

C1512584;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Casein Kinase II Subunit Alpha [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- GTPase HRas [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Insulin Receptor Substrate 1 [NCIt concept]
- Insulin-Like Growth Factor 1 Receptor [NCIt concept]
- Insulin-Like Growth Factor I [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- Ras GTPase-Activating Protein 1 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Serum Response Factor [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 11 [NCIt concept]
pathway_has_gene_element
- CSNK2A1 wt Allele [NCIt concept]
- ELK1 wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IGF1 wt Allele [NCIt concept]
- IGF1R wt Allele [NCIt concept]
- IRS1 wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PTPN11 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- RASA1 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SRF wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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