PLK1 wt Allele

Preferred Label : PLK1 wt Allele;

NCIt synonyms : Polo-Like Kinase (Drosophila) Gene; STPK13; PLK; PLK Gene; Polo-Like Kinase 1 wt Allele; PLK wt Allele; Polo-Like Kinase 1 (Drosophila) Gene; Polo (Drosophia)-Like Kinase Gene;

NCIt definition : Human PLK1 wild-type allele is located in the vicinity of 16p12.1 and is approximately 11 kb in length. This allele, which encodes serine/threonine-protein kinase PLK1 protein, plays a role in different stages of mitosis and modulates the spindle checkpoint at the metaphase-anaphase transition. PLK1 gene expression is a negative prognostic factor in several types of cancer such as esophageal carcinomas, gastric carcinomas, head and neck tumors, melanomas and non-small cell lung cancer.;

NCIt note : PLK1 gene expression is induced by mitogens.;

GenBank Accession Number : NM_005030;

Details

Origin ID

C51263;

UMLS CUI

C1706250;

OMIM relation
- Polo-like kinase 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 16p12.1 [NCIt concept]
gene_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
- FOXM1 Transcription Factor Signaling Pathway [NCIt concept]
- FOXO Transcription Factor Family Signaling Pathway [NCIt concept]
- Oocyte Meiosis Pathway [NCIt concept]
- PLK1 Signaling Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
gene_plays_role_in_process
- Cytokinesis [NCIt concept]
- Mitosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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