Ribosomal Protein S6 Kinase Alpha-6

Preferred Label : Ribosomal Protein S6 Kinase Alpha-6;

NCIt synonyms : 90 kDa Ribosomal Protein S6 Kinase 6; EC 2.7.11.1; p90-RSK 6; RPS6KA6; S6K-Alpha-6; Ribosomal Protein S6 Kinase 4; RSK-4; p90RSK6; Ribosomal Protein S6 Kinase A6; pp90RSK4;

NCIt definition : Ribosomal protein S6 kinase alpha-6 (745 aa, 84 kDa) is encoded by the human RPS6KA6 gene. This protein may be involved in TP53-dependent cell growth arrest signaling.;

NCIt note : Unlike other members of the 90 kDa ribosomal protein S6 kinase family, ribosomal protein S6 kinase alpha-6 appears to have constitutive serine/threonine-protein kinase activity. (UniProt);

Details

Origin ID

C181651;

UMLS CUI

C1570163;

OMIM relation
- Ribosomal protein s6 kinase a6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- RPS6KA6 protein, human [MeSH Supplementary Concept]
- RPS6KA6 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- RPS6KA6 Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Long-Term Potentiation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Oocyte Meiosis Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Nervous System Development [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
is_target
- RSK1-4 Inhibitor PMD-026 [NCIt concept]

Keyword's position in hierarchy(ies) :

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