" /> Structural Maintenance of Chromosomes Protein 3 - CISMeF





Preferred Label : Structural Maintenance of Chromosomes Protein 3;

NCIt synonyms : Bamacan Proteoglycan; Human Chromosome-Associated Polypeptide; Basement Membrane-Associated Chondroitin Proteoglycan; Bamacan; hCAP; CSPG6; Chondroitin Sulfate Proteoglycan 6; Chromosome-Asociated Polypeptide; Chondroitin Sulfate Proteoglycan-6; SMC Protein 3; SMC-3; SMC3;

NCIt definition : Structural maintenance of chromosomes protein 3 (1217 aa, 142 kDa) is encoded by the human SMC3 gene. This protein plays a role in chromosome cohesion and may be expressed as an extracellular glycoprotein that plays a role in cell-matrix adhesion.;

NCIt note : Chondroitin Sulfate Proteoglycan 6 (CSPG6), encoded by the CSPG6 gene, is an abundant secreted chondroitin sulfate proteoglycan in basement membranes and an intracellular protein. CSPG6 is involved in chromosome cohesion during cell cycle and in DNA repair as a central component of the cohesin complex, which is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis and in chromosome movement. (from LocusLink);

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12/05/2024


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