AURKA wt Allele

Preferred Label : AURKA wt Allele;

NCIt synonyms : Aurora Kinase A wt Allele; AURORA2; BTAK; STK6; AIK; STK15; ARK1; STK15 wt Allele; STK7; STK6, Mouse, Homologue of Gene; AURA; PPP1R47;

NCIt definition : Human AURKA wild-type allele is located within 20q13.2-13.3 and is approximately 23 kb in length. This allele, which encodes serine/threonine-protein kinase 6 protein, plays a regulatory role in the G2 and M phases of the cell cycle via involvement in mitotic entry, centrosome duplication and spindle assembly. Certain allelic variants of the AURKA gene are associated with breast and colon cancer. This gene is overexpressed in many types of cancer.;

NCIt note : Overexpression of the AURKA gene results in centrosome amplification, chromosomal instability, and malignant transformation of cells. Inhibition of serine/threonine-protein kinase 6 protein activity blocks cell growth and induces apoptosis in cancer cells.;

GenBank Accession Number : NM_003600;

Details

Origin ID

C51324;

UMLS CUI

C1706168;

Automatic exact mappings (from CISMeF team)
- AURA [WHO-ART Preferred Term]
- Aura [MedDRA Preferred Term]
- Aura [ICD-11 Category]
- Aura (finding) [SNOMED CT concept]
- Aurora kinase a [OMIM gene]
- Focal sensory seizure [HPO term]
- aura [MeSH concept]
- beta-adrenergic receptor kinase activity [GO term]
- epilepsy [MeSH Descriptor]
- myosin heavy chain kinase activity [GO term]
OMIM relation
- Aurora kinase a [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 20q13.2-q13.3 [NCIt concept]
gene_is_element_in_pathway
- Aurora A Signaling Pathway [NCIt concept]
- Aurora B Signaling Pathway [NCIt concept]
- Aurora Kinase Signaling Pathway [NCIt concept]
- Mitotic Spindle Regulation Pathway [NCIt concept]
- Oocyte Meiosis Pathway [NCIt concept]
- PLK1 Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Anaphase [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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