Preferred Label : Androgen Receptor Antisense Oligonucleotide AZD5312;
NCIt related terms : AZD-5312;
NCIt definition : An antisense oligonucleotide targeting the androgen receptor (AR) mRNA, with potential
antineoplastic activity. Upon intravenous administration, AZD5312 hybridizes with
AR mRNA, which blocks translation of the AR protein. This both inhibits AR-induced
tumor cell growth and promotes apoptosis in AR-overexpressing tumor cells. AR is overexpressed
in certain breast and prostate cancers and is involved in tumor cell proliferation
and survival.;
UNII : 3S31QX1Q6J;
Molecule name : ISIS-ARRx; ISIS-AZ1Rx; AZD5312;
NCI Metathesaurus CUI : CL473660;
Origin ID : C116326;
UMLS CUI : C3896832;
Semantic type(s)
- concept_is_in_subset
- has_target
