Preferred Label : 2-Hydroxyflutamide Depot;
NCIt synonyms : 2-Hydroxyflutamide Controlled-Release Formulation;
NCIt definition : A depot formulation containing a bioresorbable, controlled-release, calcium sulphate-based
paste of the nonsteroidal antiandrogen 2-hydroxyflutamide (2-HOF) with potential antineoplastic
activity. Upon injection into the tumor site in the prostate, 2-hydroxyflutamide depot
slowly releases 2-HOF, which competitively binds to androgen receptors (ARs), blocking
the binding of dihydrotestosterone (DHT). This may inhibit androgen-dependent DNA
and protein synthesis, resulting in tumor cell growth arrest and decreased cellular
proliferation. In addition, 2-HOF inhibits nuclear uptake of androgen in androgen-responsive
tissues.;
Drug name : Liproca;
NCI Metathesaurus CUI : CL412370;
Origin ID : C85482;
UMLS CUI : C2827704;
Semantic type(s)
- concept_is_in_subset
- has_target
