Preferred Label : Androgen Receptor/Glucocorticoid Receptor Antagonist CB-03-10;
NCIt synonyms : Cortexolone 17alpha-Valerate-21-propionate; AR/GR Antagonist CB-03-10;
NCIt definition : An orally bioavailable steroidal cortexolone derivative and antagonist of the androgen
receptor (AR) and glucocorticoid receptor (GR), with potential antineoplastic activity.
Upon oral administration, AR/GR antagonist CB-03-10 specifically binds to AR and GR,
inhibits AR and GR activation, and prevents AR- and GR-mediated signaling. This leads
to an induction of both extrinsic and intrinsic apoptotic pathways and inhibits cell
growth in AR- and GR-overexpressing tumor cells. AR and GR are overexpressed in certain
types of cancer cells and are involved in proliferation, survival and chemoresistance
of tumor cells.;
Molecule name : CB 03 10; CB-03-10;
NCI Metathesaurus CUI : CL1406219;
Origin ID : C172104;
UMLS CUI : C5417891;
Semantic type(s)
- concept_is_in_subset
- has_target
