Nifedipine - CISMeF

Preferred Label : Nifedipine;

NCIt definition : A dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04);

UNII : I9ZF7L6G2L;

InChIKey : HYIMSNHJOBLJNT-UHFFFAOYSA-N;

CAS number : 21829-25-4;

Drug name : Procardia; Adalat;

Chemical formula : C17H18N2O6;

ChEBI ID : CHEBI:7565;

Codes from synonyms : 30189;

Details

Origin ID

C29290;

UMLS CUI

C0028066;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- NIFEdipine [LOINC component]
- Nifedipine [ICD-11 Extension code]
- Nifedipine (substance) [SNOMED CT concept]
- Product containing nifedipine (medicinal product) [SNOMED CT concept]
- nifedipine [ATC Code]
- nifedipine [Substance BNPC]
- nifedipine [MeSH Descriptor]
- nifedipine [SNOMED Notion]
- nifedipine [MeSH concept]
Validated automatic mappings to BTNT
- nifedipine [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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