Preferred Label : Tacrolimus;
NCIt synonyms : Fujimycin;
NCIt related terms : Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone;
NCIt definition : A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12
protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin
phosphatase activity and resulting in decreased cytokine production. This agent exhibits
potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes
in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive
properties to cyclosporine, but is more potent.;
Alternative definition : NCI-GLOSS: A drug used to help reduce the risk of rejection by the body of organ and
bone marrow transplants.;
UNII : WM0HAQ4WNM;
InChIKey : NWJQLQGQZSIBAF-MLAUYUEBSA-N;
CAS number : 109581-93-3;
Drug name : Prograf; Protopic; Hecoria; Tacforius;
Molecule name : FK 506; FK-506;
Chemical formula : C44H69NO12.H2O;
NSC code : 717865;
ChEBI ID : CHEBI:61057;
Codes from synonyms : 01195; NSC0717865; CDR0000045414; 474;
Origin ID : C1311;
UMLS CUI : C0085149;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
