Calcineurin - CISMeF

Preferred Label : Calcineurin;

NCIt definition : Ubiquitous heterodimeric human Calcineurin is Ca(2 )/calmodulin-regulated protein phosphatase involved in many biologic activities as a modifier of phosphorylation status. Composed of widely expressed or tissue-restricted 55-60-kDa calmodulin-binding catalytic subunit (PPP Phosphatase/PP-2B Family) and conserved 19-kD Ca(2 )-sensitive regulatory subunit, Calcineurin appears to regulate glycolytic metabolism, nuclear translocation of NFATC1 transcription factor, sperm motility, and dopaminergic signal transduction and NMDA receptor-dependent synaptic plasticity. (NCI);

Details

Origin ID

C17275;

UMLS CUI

C5551431;

Currated CISMeF NLP mapping
- Protein phosphatase 3 [LOINC component]
- calcineurin [MeSH Descriptor]
- calcineurin [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Protein phosphatase 3 [LOINC component]
- Protein phosphatase 3 (substance) [SNOMED CT concept]
- calcineurin [MeSH concept]
- calcineurin [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_associated_anatomy
- Brain [NCIt concept]
gene_product_has_biochemical_function
- Phosphoprotein Phosphatase [NCIt concept]
gene_product_plays_role_in_biological_process
- Dephosphorylation [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Signal Transduction [NCIt concept]
has_gene_product_element
- Calcineurin Subunit B Type 1 [NCIt concept]
- Calcineurin Subunit B Type 2 [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform [NCIt concept]
is_target
- Calcineurin Inhibitor [NCIt concept]
- Tacrolimus [NCIt concept]

Keyword's position in hierarchy(ies) :

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