Calcineurin Inhibitor

Preferred Label : Calcineurin Inhibitor;

NCIt synonyms : CNI Inhibitor;

NCIt definition : Any agent that inhibits calcineurin (protein phosphatase 3; PPP3), a serine/threonine protein phosphatase dependent on calcium and calmodulin, with immunosuppressant activity. Inhibition of calcineurin prevents dephosphorylation of the transcription factor nuclear factor of activated T-cells, cytoplasmic (NFATc), which prevents its translocation to the nucleus and the subsequent induction of the expression of interleukin-2 (IL-2). This prevents IL-2-mediated proliferation and activation of T-cells, and T-lymphocyte-mediated immune responses.;

Details

Origin ID

C146638;

UMLS CUI

C1562036;

Automatic exact mappings (from CISMeF team)
- Calcineurin inhibitor (disposition) [SNOMED CT concept]
- Calcineurin inhibitors [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Calcineurin Inhibitors [MeSH concept]
- Calcineurin Inhibitors [MeSH Descriptor]
- Substance with calcineurin inhibitor mechanism of action (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing calcineurin inhibitor (product) [SNOMED CT concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Calcineurin Inhibitors [MeSH Descriptor]
- Calcineurin Inhibitors [MeSH concept]
- Product containing calcineurin inhibitor (product) [SNOMED CT concept]
- Substance with calcineurin inhibitor mechanism of action (substance) [SNOMED CT concept]
- calcineurin inhibitors [ATC Code]
Validated automatic mappings to BTNT
- calcineurin inhibitors [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
has_target
- Calcineurin [NCIt concept]

Keyword's position in hierarchy(ies) :

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