calcineurin - CISMeF

Preferred Label : calcineurin;

MeSH definition : A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.;

MeSH synonym : protein phosphatase 3; protein phosphatase-2b; protein phosphatase 2b; phosphatase 3, protein;

CISMeF synonym : b, calcineurin; 2b, protein phosphatase; a, calcineurin; phosphatase 2b, protein; phosphatase-2b, protein; EC 3.1.3.-;

CISMeF acronym : PP2B;

MeSH hyponym : calcineurin B; calcineurin A; Protein Phosphatase 3 Regulatory Subunit; Protein Phosphatase 3 Catalytic Subunit;

Registry Number MeSH : EC 3.1.3.16;

Wikipedia link : https://en.wikipedia.org/wiki/Calcineurin;

Is substance : O;

UNII : EC 3.1.3.16;

Details

Origin ID

D019703;

UMLS CUI

C0054450;

ATC code(s)
- calcineurin inhibitors [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Cyclin-Dependent Kinase Inhibitor 3 [NCIt concept]
- Dual Specificity Protein Phosphatase 1 [NCIt concept]
- Dual Specificity Protein Phosphatase 3 [NCIt concept]
- Protein Phosphatase 1D [NCIt concept]
- Protein phosphatase 3, catalytic subunit, alpha isoform [OMIM gene]
- Protein phosphatase 3, catalytic subunit, beta isoform [OMIM gene]
- calcium-dependent protein serine/threonine phosphatase activity [GO term]
- protein phosphatase 3 catalytic subunit alpha [HGNC gene]
- protein phosphatase 3 catalytic subunit beta [HGNC gene]
- protein phosphatase 3 catalytic subunit gamma [HGNC gene]
- protein phosphatase 3 regulatory subunit B, alpha [HGNC gene]
- protein phosphatase 3 regulatory subunit B, beta [HGNC gene]
- protein serine/threonine phosphatase activity [GO term]
CISMeF manual mappings
- Substance with calcineurin inhibitor mechanism of action (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Calcineurin [NCIt concept]
- Protein phosphatase 3 [LOINC component]
- Protein phosphatase 3 (substance) [SNOMED CT concept]
Indexing information
- 6-(3,4-dichlorophenyl)-4-(N,N-dimethylaminoethylthio)-2-phenylpyrimidine [MeSH Supplementary Concept]
- CBL protein, arabidopsis [MeSH Supplementary Concept]
- Dscr1l1 protein, mouse [MeSH Supplementary Concept]
- RCAN1 protein, human [MeSH Supplementary Concept]
- RCAN2 protein, human [MeSH Supplementary Concept]
- RCN1 protein, S cerevisiae [MeSH Supplementary Concept]
- SCY-641 [MeSH Supplementary Concept]
- TBC1D10C protein, mouse [MeSH Supplementary Concept]
- pimecrolimus [MeSH Supplementary Concept]
Record concept(s)
- calcineurin [MeSH concept]
- calcineurin A [MeSH concept]
- calcineurin B [MeSH concept]
Related MeSH Supplementary Concept(s)
- CMP2 protein, S cerevisiae [MeSH Supplementary Concept]
- CNA1 protein, S cerevisiae [MeSH Supplementary Concept]
- CNB1 protein, S cerevisiae [MeSH Supplementary Concept]
- CPPED1 protein, human [MeSH Supplementary Concept]
- Cabin1 protein, mouse [MeSH Supplementary Concept]
- PBO-1 protein, C elegans [MeSH Supplementary Concept]
- PPP3CA protein, human [MeSH Supplementary Concept]
- PPP3CB protein, human [MeSH Supplementary Concept]
- PPP3CB protein, rat [MeSH Supplementary Concept]
- PPP3CC protein, human [MeSH Supplementary Concept]
- PPP3CC protein, mouse [MeSH Supplementary Concept]
- PPP3R1 protein, human [MeSH Supplementary Concept]
- PPP3R2 protein, human [MeSH Supplementary Concept]
- PPP3R2 protein, mouse [MeSH Supplementary Concept]
- Ppp3r2 protein, rat [MeSH Supplementary Concept]
- calcineurin Balpha2 [MeSH Supplementary Concept]
- ppp3r1 protein, rat [MeSH Supplementary Concept]
- protein phosphatase 3, catalytic subunit, beta isoform, mouse [MeSH Supplementary Concept]
Related MeSH term(s)
- Calcineurin Inhibitors [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Calcineurin [NCIt concept]
- Protein phosphatase 3 [LOINC component]
- Protein phosphatase 3 (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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