Preferred Label : Simvastatin;
NCIt synonyms : Synvinolin; [1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl
2,2-dimethylbutanoate;
NCIt definition : A lipid-lowering agent derived synthetically from a fermentation product of the fungus
Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively
inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme
which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol
synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates
immune responses by suppressing MHC II (major histocompatibility complex II) on interferon
gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells.
(NCI04);
UNII : AGG2FN16EV;
InChIKey : RYMZZMVNJRMUDD-HGQWONQESA-N;
CAS number : 79902-63-9;
Drug name : Zocor;
Molecule name : MK 733;
Chemical formula : C25H38O5;
NSC code : 633782;
ChEBI ID : CHEBI:9150;
Codes from synonyms : 02582; 125601;
Origin ID : C29454;
UMLS CUI : C0074554;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_target
