Simvastatin - CISMeF

Preferred Label : Simvastatin;

NCIt synonyms : Synvinolin; [1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate;

NCIt definition : A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04);

UNII : AGG2FN16EV;

InChIKey : RYMZZMVNJRMUDD-HGQWONQESA-N;

CAS number : 79902-63-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 79902-63-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Zocor;

Molecule name : MK 733;

Chemical formula : C25H38O5;

NSC code : 633782;

ChEBI ID : CHEBI:9150;

Codes from synonyms : 02582;

Details

Origin ID

C29454;

UMLS CUI

C0074554;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing simvastatin (medicinal product) [SNOMED CT concept]
- Simvastatin [ICD-11 Extension code]
- Simvastatin [LOINC component]
- Simvastatin (substance) [SNOMED CT concept]
- simvastatin [ATC Code]
- simvastatin [Substance BNPC]
- simvastatin [SNOMED Notion]
- simvastatin [MeSH concept]
- simvastatin [MeSH Descriptor]
Validated automatic mappings to BTNT
- simvastatin [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase [NCIt concept]

Keyword's position in hierarchy(ies) :

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