simvastatin - CISMeF

Preferred Label : simvastatin;

MeSH definition : A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.;

CISMeF synonym : synvinolin;

DeCS synonym : Synvinolin;

MeSH hyponym : zocor; MK-733; MK 733; MK733;

MeSH Related Number : 79902-63-9 (Simvastatin);

Registry Number MeSH : 79902-63-9;

Wikipedia link : https://en.wikipedia.org/wiki/Simvastatin;

Is substance : O;

UNII : AGG2FN16EV;

InChIKey : RYMZZMVNJRMUDD-HGQWONQESA-N;

Details

Origin ID

D019821;

UMLS CUI

C0074554;

ATC code(s)
- simvastatin [ATC Code]
- simvastatin and acetylsalicylic acid [ATC Code]
- simvastatin and fenofibrate [ATC Code]
- simvastatin, acetylsalicylic acid and ramipril [ATC Code]
- sitagliptin and simvastatin [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- simvastatin [Substance BNPC]
Currated CISMeF NLP mapping
- Simvastatin [ICD-11 Extension code]
- Simvastatin [LOINC component]
- Simvastatin [NCIt concept]
- Simvastatin (substance) [SNOMED CT concept]
- simvastatin [SNOMED Notion]
Pharmacological action(s)
- hydroxymethylglutaryl-coa reductase inhibitors [MeSH Descriptor]
Record concept(s)
- MK-733 [MeSH concept]
- Synvinolin [MeSH concept]
- simvastatin [MeSH concept]
- zocor [MeSH concept]
Related MeSH Supplementary Concept(s)
- 6-(2-(8-(2,2-dimethylbutyryl)oxy)-2,6-dimethyl-5-hydroxy-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthyl-1-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one [MeSH Supplementary Concept]
- beta-hydroxy simvastatin acid [MeSH Supplementary Concept]
- simcor [MeSH Supplementary Concept]
- simvaglyzin [MeSH Supplementary Concept]
- simvastatin acid [MeSH Supplementary Concept]
- simvastatin hydroxyacid [MeSH Supplementary Concept]
See also
- Rosuvastatin Calcium [MeSH Descriptor]
See also inter- (CISMeF)
- Product containing simvastatin (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing simvastatin (medicinal product) [SNOMED CT concept]
- Simvastatin [ICD-11 Extension code]
- Simvastatin [LOINC component]
- Simvastatin [NCIt concept]
- Simvastatin (substance) [SNOMED CT concept]
- simvastatin [ATC Code]
- simvastatin [Substance BNPC]
- simvastatin [SNOMED Notion]
Validated automatic mappings to BTNT
- simvastatin [ATC Code]

Keyword's position in hierarchy(ies) :

Main resources

You can consult :

recommendations
documents concerning education
documents for patients