hydroxymethylglutaryl-coa reductase inhibitors

Preferred Label : hydroxymethylglutaryl-coa reductase inhibitors;

Obsolete resource : false;

MeSH definition : Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.; Compounds that inhibit HYDROXYMETHYLGLUTARYL COA REDUCTASES. They have been shown to directly lower CHOLESTEROL synthesis.;

MeSH synonym : inhibitors, hydroxymethylglutaryl coa; inhibitors, hmg-coa reductase; hydroxymethylglutaryl-coenzyme a inhibitors; reductase inhibitors, hmg-coa; hmg-coa reductase inhibitors; inhibitors, hydroxymethylglutaryl coenzyme a; inhibitors, hydroxymethylglutaryl-coa reductase; reductase inhibitors, hydroxymethylglutaryl-coa; statins, hmg-coa; hmg-coa statins; statins, hmg coa; inhibitors, hydroxymethylglutaryl-coa; hydroxymethylglutaryl-coa inhibitors; inhibitors, hydroxymethylglutaryl-coenzyme a; hmg coa reductase inhibitors; inhibitors, hmg coa reductase; hydroxymethylglutaryl CoA reductase inhibitors; Statins; HMG-CoA Reductase Inhibitor; HMG CoA Reductase Inhibitor; Statin; Hydroxymethylglutaryl-CoA Reductase Inhibitor; Hydroxymethylglutaryl CoA Reductase Inhibitor; Reductase Inhibitor, Hydroxymethylglutaryl-CoA;

MeSH annotation : X ref STATINS, HMG-COA: do not confuse with statin protein in SCR;

Wikipedia link : https://en.wikipedia.org/wiki/Statin;

Is substance : O;

action pharmacologique : O;

Details

Origin ID

D019161;

UMLS CUI

C0360714;

ATC code(s)
- hmg coa reductase inhibitors [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (disposition) [SNOMED CT concept]
- Administration of prophylactic statin (procedure) [SNOMED CT concept]
- HMG CoA reductase inhibitors [ICD-11 Extension code]
CISMeF manual mappings
- 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor adverse reaction (disorder) [SNOMED CT concept]
Currated CISMeF NLP mapping
- HMG-CoA Reductase Inhibitor [NCIt concept]
- Product containing 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (product) [SNOMED CT concept]
- Substance with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor mechanism of action (substance) [SNOMED CT concept]
- hmg coa reductase inhibitors [ATC Code]
- hmg-coa reductase inhibitor, nos [SNOMED Notion]
- statins [MedlinePlus Topic]
Indexing information
- 7-(4-((3-fluorobenzyl)carbamoyl)-5-cyclopropyl-2-(4-fluorophenyl)-1H-imidazol-1-yl)-3,5-dihydroxyheptanoic acid [MeSH Supplementary Concept]
- coenzyme Q10 [MeSH Supplementary Concept]
- tocomin [MeSH Supplementary Concept]
MeSH Descriptor(s) used for indexing
- Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent [MeSH Descriptor]
- hydroxymethylglutaryl CoA reductases [MeSH Descriptor]
MedlinePlus topic(s)
- statins [MedlinePlus Topic]
Record concept(s)
- Hydroxymethylglutaryl-CoA reductase inhibitors [MeSH concept]
See also
- hydroxymethylglutaryl CoA reductases [MeSH Descriptor]
See also inter- (CISMeF)
- Drug-induced photosensitivity (disorder) [SNOMED CT concept]
- Myalgia caused by statin (finding) [SNOMED CT concept]
- Rhabdomyolysis due to statin (disorder) [SNOMED CT concept]
- Susceptibility to myopathies due to statin treatment [ORDO Disease]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Substance(s)
- 2,6,7-trideoxy-7-C-(2,4-dichlorophenyl)heptonic acid [MeSH Supplementary Concept]
- 2-(2-(3-hydroxy-12-(2-methyl-1-oxobutoxy)-5-androstan-17-yl)ethyl)tetrahydro-4-hydroxy-2H-pyran-6-one [MeSH Supplementary Concept]
- 3,24-dihydroxycholest-8(14)-en-15-one [MeSH Supplementary Concept]
- 3,25-dihydroxycholest-8(14)-en-15-one [MeSH Supplementary Concept]
- 3,4-dihydroxyphenylpropionylleucinamide [MeSH Supplementary Concept]
- 3-hydroxy-24-dimethylaminochol-8(14)-en-15-one [MeSH Supplementary Concept]
- 3-hydroxy-25,26,26,26,27,27,27-heptafluoro-5-cholest-8(14)-en-15-one [MeSH Supplementary Concept]
- 3-hydroxycholest-8(14),24-dien-15-one [MeSH Supplementary Concept]
- 6-(2,4-dichlorophenyl)-2,3,4-trihydroxyhexanesulfonic acid [MeSH Supplementary Concept]
- 6-(2,4-dichlorophenyl)-2,4-dihydroxyhexane-1-sulfonic acid [MeSH Supplementary Concept]
- 6-(2,4-dichlorophenyl)-erythro-2,4-dihydroxyhexylphosphonic acid [MeSH Supplementary Concept]
- 6-(2-(2,4-dichloro-6-hydroxyphenyl)ethyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one [MeSH Supplementary Concept]
- 6-(2-(8-((4-fluorobenzyl)oxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl)ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one [MeSH Supplementary Concept]
- 6-hydroxyisocompactin [MeSH Supplementary Concept]
- 7-(2'-((2''-methyl-1''-oxobutoxy)methyl)-1'-cyclohexyl)-3-hydroxy-5-oxoheptanoic acid [MeSH Supplementary Concept]
- 7-(2,4-dichlorophenyl)-3-hydroxy-5-heptanolide [MeSH Supplementary Concept]
- 7-(3-bromo-4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-pyrrol-1-yl)-3,5-dihydroxy-6-heptenoic acid methyl ester [MeSH Supplementary Concept]
- 7-(3-hydroxy-2-methyl-1,2,3,5,6,7,8,8a-octahydro-1-naphtalenyl)-3,5-dihydroxyheptanoic acid [MeSH Supplementary Concept]
- 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid [MeSH Supplementary Concept]
- Atorvastatin [MeSH Descriptor]
- BMY 21950 [MeSH Supplementary Concept]
- GR 92549 [MeSH Supplementary Concept]
- GR 95030X [MeSH Supplementary Concept]
- HR 780 [MeSH Supplementary Concept]
- L 157012 [MeSH Supplementary Concept]
- L 645164 [MeSH Supplementary Concept]
- L 647318 [MeSH Supplementary Concept]
- L 669262 [MeSH Supplementary Concept]
- PD 123244-15 [MeSH Supplementary Concept]
- RP 61969 [MeSH Supplementary Concept]
- Rosuvastatin Calcium [MeSH Descriptor]
- SQ 33600 [MeSH Supplementary Concept]
- SRI 62320 [MeSH Supplementary Concept]
- amlodipine, atorvastatin drug combination [MeSH Supplementary Concept]
- cerivastatin [MeSH Supplementary Concept]
- cholest-8-ene-3,15-diol [MeSH Supplementary Concept]
- chrysosporin [MeSH Supplementary Concept]
- crilvastatin [MeSH Supplementary Concept]
- dihydrocompactin [MeSH Supplementary Concept]
- dihydromevinolin [MeSH Supplementary Concept]
- fermodulin [MeSH Supplementary Concept]
- lanost-8-en-3-ol-24-one [MeSH Supplementary Concept]
- lovastatin [MeSH Descriptor]
- meglutol [MeSH Descriptor]
- methoxypolyethoxylated cholesterol [MeSH Supplementary Concept]
- mevastatin [MeSH Supplementary Concept]
- pannorin [MeSH Supplementary Concept]
- phosphoadenosine diphosphoribose [MeSH Supplementary Concept]
- pitavastatin [MeSH Supplementary Concept]
- pravastatin [MeSH Descriptor]
- red yeast rice [MeSH Supplementary Concept]
- simvastatin [MeSH Descriptor]
UMLS correspondences (same concept)
- HMG-CoA Reductase Inhibitor [NCIt concept]
- Product containing 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (product) [SNOMED CT concept]
- Substance with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor mechanism of action (substance) [SNOMED CT concept]
- hmg-coa reductase inhibitor, nos [SNOMED Notion]
- statins [MedlinePlus Topic]

Keyword's position in hierarchy(ies) :

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