hydroxymethylglutaryl CoA reductases

Preferred Label : hydroxymethylglutaryl CoA reductases;

MeSH definition : Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl-coenzyme A to yield MEVALONIC ACID.;

MeSH synonym : 3-hydroxy-3-methylglutaryl coa reductase; reductase, 3-hydroxy-3-methylglutaryl coa; hmg coa reductase; coa reductase, 3-hydroxy-3-methylglutaryl; 3 hydroxy 3 methylglutaryl coa reductase; hydroxymethylglutaryl coa reductase; hmg coa reductases;

Registry Number MeSH : EC 1.1.1.-;

Is substance : O;

Details

Origin ID

D006903;

UMLS CUI

C0020374;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase [NCIt concept]
- 3-hydroxy-3-methylglutaryl-coa reductase [OMIM Phenotype]
- hydroxymethylglutaryl-coa reductase (nadph) [SNOMED Notion]
Currated CISMeF NLP mapping
- Hydroxymethylglutaryl-coenzyme A reductase (substance) [SNOMED CT concept]
- hydroxymethylglutaryl-coa reductase [SNOMED Notion]
Indexing information
- 2,6,7-trideoxy-7-C-(2,4-dichlorophenyl)heptonic acid [MeSH Supplementary Concept]
- 2-(2-(3-hydroxy-12-(2-methyl-1-oxobutoxy)-5-androstan-17-yl)ethyl)tetrahydro-4-hydroxy-2H-pyran-6-one [MeSH Supplementary Concept]
- 3,24-dihydroxycholest-8(14)-en-15-one [MeSH Supplementary Concept]
- 3,25-dihydroxycholest-8(14)-en-15-one [MeSH Supplementary Concept]
- 3,4-dihydroxyphenylpropionylleucinamide [MeSH Supplementary Concept]
- 3-hydroxy-24-dimethylaminochol-8(14)-en-15-one [MeSH Supplementary Concept]
- 3-hydroxy-25,26,26,26,27,27,27-heptafluoro-5-cholest-8(14)-en-15-one [MeSH Supplementary Concept]
- 3-hydroxycholest-8(14),24-dien-15-one [MeSH Supplementary Concept]
- 6-(2,4-dichlorophenyl)-2,3,4-trihydroxyhexanesulfonic acid [MeSH Supplementary Concept]
- 6-(2,4-dichlorophenyl)-2,4-dihydroxyhexane-1-sulfonic acid [MeSH Supplementary Concept]
- 6-(2,4-dichlorophenyl)-erythro-2,4-dihydroxyhexylphosphonic acid [MeSH Supplementary Concept]
- 6-(2-(2,4-dichloro-6-hydroxyphenyl)ethyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one [MeSH Supplementary Concept]
- 6-(2-(8-((4-fluorobenzyl)oxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl)ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one [MeSH Supplementary Concept]
- 6-hydroxyisocompactin [MeSH Supplementary Concept]
- 7-(2'-((2''-methyl-1''-oxobutoxy)methyl)-1'-cyclohexyl)-3-hydroxy-5-oxoheptanoic acid [MeSH Supplementary Concept]
- 7-(2,4-dichlorophenyl)-3-hydroxy-5-heptanolide [MeSH Supplementary Concept]
- 7-(2-(4-fluorophenyl)-4-isopropyl-5-(4-methylbenzylcarbamoyl)-2H-pyrazol-3-yl)-3,5-dihydroxyheptanoic acid [MeSH Supplementary Concept]
- 7-(3-bromo-4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-pyrrol-1-yl)-3,5-dihydroxy-6-heptenoic acid methyl ester [MeSH Supplementary Concept]
- 7-(3-hydroxy-2-methyl-1,2,3,5,6,7,8,8a-octahydro-1-naphtalenyl)-3,5-dihydroxyheptanoic acid [MeSH Supplementary Concept]
- 7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid [MeSH Supplementary Concept]
- 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid [MeSH Supplementary Concept]
- BMY 21950 [MeSH Supplementary Concept]
- GR 92549 [MeSH Supplementary Concept]
- GR 95030X [MeSH Supplementary Concept]
- HR 780 [MeSH Supplementary Concept]
- L 157012 [MeSH Supplementary Concept]
- L 645164 [MeSH Supplementary Concept]
- L 647318 [MeSH Supplementary Concept]
- L 669262 [MeSH Supplementary Concept]
- PD 123244-15 [MeSH Supplementary Concept]
- RP 61969 [MeSH Supplementary Concept]
- SQ 33600 [MeSH Supplementary Concept]
- SRI 62320 [MeSH Supplementary Concept]
- cholest-8-ene-3,15-diol [MeSH Supplementary Concept]
- chrysosporin [MeSH Supplementary Concept]
- crilvastatin [MeSH Supplementary Concept]
- dihydrocompactin [MeSH Supplementary Concept]
- dihydromevinolin [MeSH Supplementary Concept]
- fermodulin [MeSH Supplementary Concept]
- lanost-8-en-3-ol-24-one [MeSH Supplementary Concept]
- methoxypolyethoxylated cholesterol [MeSH Supplementary Concept]
- pannorin [MeSH Supplementary Concept]
Record concept(s)
- hydroxymethylglutaryl CoA reductases [MeSH concept]
Related MeSH Supplementary Concept(s)
- HMG2 protein, S cerevisiae [MeSH Supplementary Concept]
- HMGCR protein, human [MeSH Supplementary Concept]
- Hmgcr protein, mouse [MeSH Supplementary Concept]
Related MeSH term(s)
- hydroxymethylglutaryl-coa reductase inhibitors [MeSH Descriptor]
See also
- hydroxymethylglutaryl-coa reductase inhibitors [MeSH Descriptor]
See also inter- (CISMeF)
- Hydroxymethylglutaryl-coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate) (substance) [SNOMED CT concept]
- hydroxymethylglutaryl-coa reductase (nadph) [SNOMED Notion]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Hydroxymethylglutaryl-coenzyme A reductase (substance) [SNOMED CT concept]
- hydroxymethylglutaryl-coa reductase [SNOMED Notion]
Validated automatic mappings to BTNT
- 3-hydroxy-3-methylglutaryl-coa reductase [OMIM Phenotype]

Keyword's position in hierarchy(ies) :

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