3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase

Preferred Label : 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase;

NCIt synonyms : EC 1.1.1.34; HMGCR; HMG-CoA Reductase; HMG CoA Reductase;

NCIt definition : 3-hydroxy-3-methylglutaryl-coenzyme A reductase (888 aa, 97 kDa) is encoded by the human HMGCR gene. This protein is involved in cholesterol synthesis.;

NCIt note : 3-hydroxy-3-methylglutaryl-coenzyme A reductase converts HMG-CoA to mevalonic acid, a cholesterol precursor.;

Details

Origin ID

C54701;

UMLS CUI

C2975999;

Currated CISMeF NLP mapping
- 3-hydroxy-3-methylglutaryl-coa reductase [OMIM Phenotype]
OMIM relation
- 3-hydroxy-3-methylglutaryl-coa reductase [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HMGCR protein, human [MeSH concept]
- HMGCR protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HMGCR Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Atorvastatin [NCIt concept]
- Atorvastatin Calcium [NCIt concept]
- Atorvastatin Sodium [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Sterol Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cholesterol Homeostasis [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Triglyceride Metabolism [NCIt concept]
is_target
- Atorvastatin Calcium [NCIt concept]
- Ezetimibe/Simvastatin [NCIt concept]
- Fluvastatin Sodium [NCIt concept]
- Lovastatin [NCIt concept]
- Pravastatin [NCIt concept]
- Pravastatin Sodium [NCIt concept]
- Rosuvastatin [NCIt concept]
- Rosuvastatin Calcium [NCIt concept]
- Simvastatin [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients