" /> Rosuvastatin - CISMeF





Preferred Label : Rosuvastatin;

NCIt definition : A statin with antilipidemic and potential antineoplastic activities. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. In addition, rosuvastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cell types; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades.;

UNII : 413KH5ZJ73;

InChIKey : BPRHUIZQVSMCRT-VEUZHWNKSA-N;

CAS number : 287714-41-4;

Chemical formula : C22H28FN3O6S;

ChEBI ID : CHEBI:38545;

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08/05/2025


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