Preferred Label : Pravastatin Sodium;
NCIt synonyms : Pravastatin;
NCIt definition : The sodium salt of pravastatin with cholesterol-lowering and potential antineoplastic
activities. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme
A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate,
a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein
levels, and modulates immune responses by suppressing MHC II (major histocompatibility
complex II) on interferon gamma-stimulated, antigen-presenting cells such as human
vascular endothelial cells. In addition, pravastatin, like other statins, exhibits
pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety
of tumor cells; these antineoplastic activities may be due, in part, to inhibition
of the isoprenylation of Ras and Rho GTPases and related signaling cascades.;
Alternative definition : NCI-GLOSS: A drug used to lower the amount of cholesterol in the blood and to prevent
stroke and heart attack. It is also being studied in the treatment of cancer and other
conditions. Pravastatin sodium blocks an enzyme that helps make cholesterol in the
body. It may also make tumor cells more sensitive to anticancer drugs. It is a type
of HMG-CoA reductase inhibitor, a type of statin, and a type of chemosensitizer.;
UNII : 3M8608UQ61;
InChIKey : VWBQYTRBTXKKOG-IYNICTALSA-M;
CAS number : 81131-70-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 81131-70-6
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Pravachol;
Chemical formula : C23H35O7.Na;
ChEBI ID : CHEBI:8361;
Codes from synonyms : 20414; CDR0000618548;
Origin ID : C29375;
UMLS CUI : C0700474;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
