Pravastatin - CISMeF

Preferred Label : Pravastatin;

NCIt synonyms : Pravastatin Base;

NCIt related terms : [1S-[1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha]]-1,2,6,7,8,8a-Hexahydro-beta,!d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid;

NCIt definition : A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04);

Alternative definition : NCI-GLOSS: The active ingredient in a drug used to lower the amount of cholesterol in the blood and to prevent stroke and heart attack. It is also being studied in the treatment of cancer and other conditions. Pravastatin blocks an enzyme that helps make cholesterol in the body. It may also make tumor cells more sensitive to anticancer drugs. It is a type of HMG-CoA reductase inhibitor, a type of statin, and a type of chemosensitizer.;

UNII : KXO2KT9N0G;

InChIKey : TUZYXOIXSAXUGO-PZAWKZKUSA-N;

CAS number : 81093-37-0;

Chemical formula : C23H36O7;

ChEBI ID : CHEBI:63618;

Codes from synonyms : 02539; CDR0000430875; 416;

Details

Origin ID

C62070;

UMLS CUI

C0085542;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pravastatin [ICD-11 Extension code]
- Pravastatin [LOINC component]
- Pravastatin (substance) [SNOMED CT concept]
- Product containing pravastatin (medicinal product) [SNOMED CT concept]
- pravastatin [ATC Code]
- pravastatin [MeSH concept]
- pravastatin [SNOMED Notion]
- pravastatin [MeSH Descriptor]
Validated automatic mappings to BTNT
- pravastatin [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
has_salt_form
- Pravastatin Sodium [NCIt concept]
has_target
- 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase [NCIt concept]
is_free_acid_or_base_form_of
- Pravastatin Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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